Genomics and transcriptomics in veterinary oncology (Review)

The sequencing of the canine genome, combined with additional genomic technologies, has created opportunities for research linking veterinary genomics naturally occurring cancer in dogs. Also, as numerous cancers have features common human cancers, comparative studies can be performed to evaluate use dogs models cancer. There been several reviews but, best our knowledge, there no comprehensive review literature genomics. PubMed and CAB Abstracts databases were searched retrieve relevant using search terms ‘veterinary’, ‘cancer’ or ‘oncology’, ‘genomics’ ‘transcriptomics’. Results manually assessed grouped based on techniques used, type investigated lesions targeted. resulted retrieval 44 transcriptomic studies, most technique employed being hybridization. Across both fields, commonly studied was osteosarcoma. Genomic aberrations often reflected those reported corresponding cancers. Analysis indicated that employing technologies instrumental developing understanding origin, development pathogenesis However, their oncology is at an early phase, appears comparatively little certain types contrast forms. Aberrations detected all tumors tabulated, results osteosarcoma, lymphoma leukemia, mast cell tumor, transmissible venereal tumor urothelial carcinoma discussed detail.